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August 18, 2026 · Side-by-side comparison authority

Compounded Tirzepatide vs Compounded Semaglutide: Which Molecule at Which Price

Both molecules are widely available as compounded product, at different prices and with different regulatory situations. Here's the direct comparison.

The Price Comparison

AttributeCompounded SemaglutideCompounded Tirzepatide
Compounded injectable range$149-$299/mo$199-$349/mo
Compounded oral range$99-$179/mo$167-$229/mo
Regulatory footing (injectable)Post-shortage personalizationPost-shortage personalization
Regulatory footing (oral)Competes with Wegovy pillNo brand oral competitor
Weight loss magnitude~15% at maintenance~20% at maintenance

Embody

Injectable semaglutide, $400 CPA tier

Injectable semaglutide only — lead compounded option.

  • Injectable semaglutide focus
  • Standard titration
  • Direct pharmacy shipping
FDA note: Compounded GLP-1 medications are not FDA-approved. Personalization must be based on a documented clinical need per current FDA guidance.
Check Latest Pricing

Telos Rx

Compounded tirzepatide

Compounded tirzepatide via direct pharmacy.

  • Compounded tirzepatide
  • Direct-link intake
  • Verify pricing
FDA note: Compounded GLP-1 medications are not FDA-approved. Personalization must be based on a documented clinical need per current FDA guidance.
Check Latest Pricing

The Efficacy Difference

The molecule-level efficacy difference (tirzepatide > semaglutide on average magnitude) carries into compounded product. Compounded tirzepatide at maintenance doses generally produces greater weight loss than compounded semaglutide at maintenance doses. The gap parallels what brand product produces.

The Regulatory Difference

Compounded oral tirzepatide has stronger regulatory footing than compounded oral semaglutide because Wegovy pill exists commercially and competes directly with compounded oral semaglutide. Compounded injectable is on similar regulatory footing between molecules — both require patient-specific personalization documentation post-ruling.

MadeMed

Compounded GLP-1 options

Independent compounder — sema, tirz, and oral formats.

  • Compounded sema/tirz
  • Oral tirz $167-229
  • Direct pharmacy fulfillment
FDA note: Compounded GLP-1 medications are not FDA-approved. Personalization must be based on a documented clinical need per current FDA guidance.
Check Latest Pricing

Wellorithm

Sema ~$147/mo, tirz ~$249/mo

Compounded GLP-1 with dose-tier pricing.

  • Sema and tirz options
  • Tier pricing by dose
  • Verify at intake
FDA note: Compounded GLP-1 medications are not FDA-approved. Personalization must be based on a documented clinical need per current FDA guidance.
Check Latest Pricing

Cost-per-Pound Framing

At maintenance dose: compounded semaglutide at $200/month producing 25 pounds of loss in a 200-pound patient = $96/pound over 12 months. Compounded tirzepatide at $300/month producing 40 pounds = $90/pound. Roughly comparable per-pound cost, different molecules and different absolute cost.

This framing helps clarify that "cheaper monthly" doesn't necessarily mean "cheaper per outcome." Pick the molecule that fits your priorities, not just the one with the lower headline price.

SHED

Starts lower, $399/mo at 7.5mg+

Note: SHED's price jumps to $399/mo at 7.5mg+.

  • Lower entry pricing
  • Price jump at 7.5mg+
  • Compounded sema + tirz
FDA note: Compounded GLP-1 medications are not FDA-approved. Personalization must be based on a documented clinical need per current FDA guidance.
Check Latest Pricing

Oak Weight Loss

GLP-1 program

Telehealth program with compounded GLP-1 access.

  • Compounded GLP-1
  • Standard intake
  • Membership pricing
FDA note: Compounded GLP-1 medications are not FDA-approved. Personalization must be based on a documented clinical need per current FDA guidance.
Check Latest Pricing

Choosing Between Them

Choose compounded semaglutide if: cost is the primary driver, target weight loss is moderate, or you want the more-studied molecule. Choose compounded tirzepatide if: maximum weight loss is the priority, budget accommodates the higher tier, or you've tried semaglutide with insufficient response.

Care Bare Rx

GLP-1 weight loss program

Telehealth prescribing with compounded fulfillment.

  • Compounded GLP-1 options
  • Weight-loss intake
  • Verify pricing at intake
FDA note: Compounded GLP-1 medications are not FDA-approved. Personalization must be based on a documented clinical need per current FDA guidance.
Check Latest Pricing

Found Health

$100 off promo

Brand-name GLP-1 access with coaching layer.

  • Brand-name focus
  • Coaching + accountability
  • Insurance-coordinated
Check Latest Pricing

Where to Start

Embody

Injectable semaglutide, $400 CPA tier

Injectable semaglutide only — lead compounded option.

  • Injectable semaglutide focus
  • Standard titration
  • Direct pharmacy shipping
FDA note: Compounded GLP-1 medications are not FDA-approved. Personalization must be based on a documented clinical need per current FDA guidance.
Check Latest Pricing

Wellorithm

Sema ~$147/mo, tirz ~$249/mo

Compounded GLP-1 with dose-tier pricing.

  • Sema and tirz options
  • Tier pricing by dose
  • Verify at intake
FDA note: Compounded GLP-1 medications are not FDA-approved. Personalization must be based on a documented clinical need per current FDA guidance.
Check Latest Pricing

MadeMed

Compounded GLP-1 options

Independent compounder — sema, tirz, and oral formats.

  • Compounded sema/tirz
  • Oral tirz $167-229
  • Direct pharmacy fulfillment
FDA note: Compounded GLP-1 medications are not FDA-approved. Personalization must be based on a documented clinical need per current FDA guidance.
Check Latest Pricing
Medical & editorial disclaimer. This article is for informational purposes only and is not medical advice. GLP-1 medications require prescriber evaluation. Compounded GLP-1 medications are not FDA-approved. Talk to a licensed clinician before starting, stopping, or changing any prescription. Provider pricing, availability, and program terms change frequently — verify current details on each provider's site before making a decision. Some links are affiliate links, which means we may earn a commission if you sign up; this does not change our recommendations or the price you pay.